Network members are actively engaged in both clinical and translational research into children’s allergies and anaphylaxis, as well as new methods of teaching. A number of members are affiliated with Universities in the North West of England, particularly the University of Manchester.

Self-funding students wishing to embark on post-graduate degrees (MD or PhD) with Network members are invited to contact the Network Administrator laurie.niland@cmft.nhs.uk attaching their up to date CV.

Network Publications

Sinnott L, Dudley-Southern R. Developing allergy services in the North West of England. Lessons Learnt. North West Allergy and Clinical Immunology Network.NWACIN Allergy Report_final

PEER-REVIEWED PUBLICATIONS (last 5 years)

2016

Giavi S, Vissers YM, Muraro A, Lauener R, Konstantinopoulos AP, Mercenier A, Wermeille A, Lazzarotto F, Frei R, Bonaguro R, Summermatter S, Nutten S, Papadopoulos NG. Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children. Allergy. 2016;71:1575-1584.
Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016 Oct 17.
Głobińska A, Pawełczyk M, Piechota-Polańczyk A, Olszewska-Ziąber A, Moskwa S, Mikołajczyk A, Jabłońska A, Zakrzewski P, Brauncajs M, Jarzębska M, Taka S, Papadopoulos NG, Kowalski ML. Impaired virus replication and decreased innate immune responses to viral infections in nasal epithelial cells from patients with allergic rhinitis. Clin Exp Immunol. 2016 Sep 26.
Kristiansen M, Dhami S, Netuveli G, Halken S, Muraro A, Roberts G, Larenas-Linnemann D, Calderón MA, Penagos M, Du Toit G, Ansotegui IJ, Kleine-Tebbe J, Lau S, Matricardi PM, Pajno G, Papadopoulos NG, Pfaar O, Ryan D, Santos AF, Timmermanns F, Wahn U, Sheikh A. Allergen immunotherapy for the prevention of allergy: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2016 Sep 21.
Bousquet J, Schünemann HJ, Hellings PW, Arnavielhe S, Bachert C, Bedbrook A, Bergmann KC, Bosnic-Anticevich S, Brozek J, Calderon M, Canonica GW, Casale TB, Chavannes NH, Cox L, Chrystyn H, Cruz AA, Dahl R, De Carlo G, Demoly P, Devillier P, Dray G, Fletcher M, Fokkens WJ, Fonseca J, Gonzalez-Diaz SN, Grouse L, Keil T, Kuna P, Larenas-Linnemann D, Lodrup Carlsen KC, Meltzer EO, Mullol J, Muraro A, Naclerio RN, Palkonen S, Papadopoulos NG, Passalacqua G, Price D, Ryan D, Samolinski B, Scadding GK, Sheikh A, Spertini F, Valiulis A, Valovirta E, Walker S, Wickman M, Yorgancioglu A, Haahtela T, Zuberbier T; MASK study group. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. J Allergy Clin Immunol. 2016;138:367-374.
Hochwallner H, Schulmeister U, Swoboda I, Focke-Tejkl M, Reininger R, Civaj V, Campana R, Thalhamer J, Scheiblhofer S, Balic N, Horak F, Ollert M, Papadopoulos NG, Quirce S, Szepfalusi Z, Herz U, van Tol EA, Spitzauer S, Valenta R. Infant milk formulas differ regarding their allergenic activity and induction of T-cell and cytokine responses. Allergy. 2016 Jul 25. 
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilò MB, Blank S, Bohle B, Bosshard PP, Breiteneder H, Brough HA, Caraballo L, Caubet JC, Crameri R, Davies JM, Douladiris N, Ebisawa M, EIgenmann PA, Fernandez-Rivas M, Ferreira F, Gadermaier G, Glatz M, Hamilton RG, Hawranek T, Hellings P, Hoffmann-Sommergruber K, Jakob T, Jappe U, Jutel M, Kamath SD, Knol EF, Korosec P, Kuehn A, Lack G, Lopata AL, Mäkelä M, Morisset M, Niederberger V, Nowak-Węgrzyn AH, Papadopoulos NG, Pastorello EA, Pauli G, Platts-Mills T, Posa D, Poulsen LK, Raulf M, Sastre J, Scala E, Schmid JM, Schmid-Grendelmeier P, van Hage M, van Ree R, Vieths S, Weber R, Wickman M, Muraro A, Ollert M. EAACI Molecular Allergology User's Guide. Pediatr Allergy Immunol. 2016;27 Suppl 23:1-250. 
Grabenhenrich LB, Dölle S, Moneret-Vautrin A, Köhli A, Lange L, Spindler T, Ruëff F, Nemat K, Maris I, Roumpedaki E, Scherer K, Ott H, Reese T, Mustakov T, Lang R, Fernandez-Rivas M, Kowalski ML, Bilò MB, Hourihane JO, Papadopoulos NG, Beyer K, Muraro A, Worm M. Anaphylaxis in children and adolescents: the European Anaphylaxis Registry. J Allergy Clin Immunol. 2016 Apr;137(4):1128-37.
Aab A, Wirz O, van de Veen W, Söllner S, Stanic B, Rückert B, Aniscenko J, Edwards MR, Johnston SL, Papadopoulos NG, Rebane A, Akdis CA, Akdis M. Human rhinoviruses enter and induce proliferation of B lymphocytes. Allergy. 2016 May 11.
Jang J, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim S-H, Arkwright PD, Takamori K, Matsuda H, Tanaha A. Skin pH is the master switch of kallikrein-5-mediated skin barrier destruction in a murine atopic dermatitis model. J Invest Dermatol. 2016;136:127-35. 

2015

Lumsden CJ, Byrne-Davis LM, Mooney JS, Sandars J. Using mobile devices for teaching and learning in clinical medicine. Arch Dis Child Educ Pract Ed 2015;100:244-51.
Tanaka A, Matsuda A, Jung K, Jang H, Makita Y, Amagai Y, Takai M, Oida K, Nishikawa S, Ishizaka S, Arkwright PD, Matsuda H. Ultra-pure soft water ameliorates atopic skin disease by preventing metallic soap deposition. Acta Dermato-Venereologica 2015;95:787-91.
Wilson RP, Ives ML, Kobayashi M, Arkwright PD, Peake J, Wong M, Adelstein S, Smart JM, French MA, Fulcher DA, McCluskey J, Casanova JL, Holland SM, Uzel G, Tangye SG, Deenick EK. STAT3 is a critical cell intrinsic regulator of unconventional T cell numbers and function. J Exp Med 2015;212:855-64.
Diacono D, Pumphrey RS, Sharma V, Arkwright PD. The deep fascia of the thigh forms an impenetrable barrier to fluid injected subcutaneously by auto-injectors. J Allergy Clin Immunol Pract 2015:3:297-9.
Turner PJ, Gowland MH, Sharma V, Lerodiakonou D, Harper N, Garcez T, Pumphrey R, Boyle RJ. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992-2012. J Allergy Clin Immunol 2015;135:956-63.
Engelhardt KR, Gertz ME, Keles S, Schäffer AA, Sigmund EC, Glocker C, Saghafi S, Pourpak Z, Ceja R, Sassi A, Graham LE, Massaad MJ, Mellouli F, Ben-Mustapha I, Khemiri M, Kilic SS, Etzioni A, Freeman AF, Thiel J, Schulze I, Al-Herz W, Metin A, Sanal Ö, Tezcan I, Yeganeh M, Niehues T, Dueckers G, Weinspach S, Patiroglu T, Unal E, Dasouki M, Yilmaz M, Genel F, Aytekin C, Kutukculer N, Somer A, Kilic M, Reisli I, Camcioglu Y, Gennery AR, Cant AJ, Jones A, Gaspar BH, Arkwright PD, Pietrogrande MC, Baz Z, Al-Tamemi S, Lougaris V, Lefranc G, Megarbane A, Boutros J, Galal N, Bejaoui M, Barbouche MR, Geha RS, Chatila TA, Grimbacher B. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol 2015;136:402-12.

2014

Mooney JS, Cappelli T, Byrne-Davis L, Lumsden CJ. How we developed eForms: an electronic form and data capture tool to support assessment in mobile medical education. Med Teach 2014;36:1032-7.
Jolles S, Williams P, Carne E, Mian H, Huissoon A, Wong G, Hackett S, Lortan J, Platts V, Longhurst H, Grigoriadou S, Dempster J, Deacock S, Kahn S, Darroch J, Simon C, Thomas M, Pavaladurai V, Alachkar H, Herwadker A, Abinun M, Arkwright P, Tarzi M, Helbert M, Bangs C, Pastacaldi C, Phillips C, Bennett H, El-Shanawany T. A UK National Audit of Hereditary and Acquired Angioedema. Clin Exp Immunol 2014;175:59-67.

2013

Arkwright PD, Summers CW, Riley BJ, Al Sediq N, Pumphrey SH. IgE sensitization to the non-specific lipid transfer protein Ara h 9 and peanut-associated bronchospasm. BioMed Research Internat 2013 Sept 12
Bewick DC, Wright NB, Pumphrey RS, Arkwright PD. Anatomical and anthropometric determinants of intramuscular versus subcutaneous administration in children with epinephrine auto-injectors. J Allergy Clin Immunol In Practice 2013;1:642-4.
Deenick EK, Avery DT, Chan A, Ma CS, Berglund LJ, Ives ML, Moens L, Stoddard JL, Bustamante J, Boisson-Dupuis S, Tsumura M, Kobayashi M, Arkwright PD, Averbuch D, Engelhard D, Magdorf K, Roesler J, Peake J, Wong M, Adelstein S, Choo S, Smart JM, French MA, Fulcher DA, Cook MC, Picard C, Durandy A, Klein C, Holland SM, Uzel G, Casanova JL, Ma CS, Tangye SG. Naïve and memory human B cells have distinct requirements for STAT3 activation for their differentiation into antibody-secreting plasma cells. J Exp Med 2013;210:2739-53.
Berglund LJ, Ma CS, Avery DT, Moens L, Deenick EK, Bustamante J, Boisson-Dupuis S, Wong M, Adelstein S, Arkwright PD, Fuchler DA, Zeigler JB, Smart JM, Kobayashi M, Casanova JL, Cook MC, Uzel G, Tangye SG. IL-21 signalling via STAT3 primes naïve human B cells to respond to IL-2. Blood 2013;122:3940-3950.
Crawford G, Enders A, Gileadi U, Stankovic S, Zhang Q, Lambe T, Crockford TL, Lockstone HE, Freeman A, Arkwright PD, Smart JM, Ma CS, Tangye SG, Goodnow CC, Cerundolo V, Godfrey DI, Su HC, Randall KL, Cornall RC. DOCK8 is critical for the survival and function of NKT cells. Blood 2013;122:2052-61.
Sharma V, Harper NJ, Garcez T, Arkwright PD. Allergic reaction to mepivacaine in a child. Br J Anaes 2013;110:1059-60.
de Klerk TA, Sharma V, Arkwright PD, Biswas S. Severe vernal keratoconjunctivitis successfully treated with subcutaneous omalizumab. J AAPOS 2013 Apr 19 pii:S1091-8531.
Ives ML, Ma CS, Palendira U, Chan A, Bustamante J, Boisson-Dupuis S, Arkwright PD, Engelhard D, Averbuch D, Magdorf K, Roesler J, Peake J, Wong M, Adelstein S, Choo S, Smart JM, French MA, Fulcher DA, Cook MC, Picard C, Durandy A, Tsumura M, Kobayashi M, Uzel G, Casanova JL, Tangye SG, Deenick EK. Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper IgE syndrome impair human CD8(+) T-cell memory formation and function. J Allergy Clin Immunol 2013;132:400-411.

2012

Beaumont DR, Arkwright PD. Factors determining the effectiveness of oral ciclosporin in the treatment of severe childhood atopic dermatitis. J Dermatolog Treat 2012;23:318-22.
Noimark L, Wales J, Du Toit G, Pastacaldi C, Haddad D, Gardner J, Hyer W, Vance G, Townshend C, Alfaham M, Arkwright PD, Rao R, Kapoor S, Summerfield A, Warner JO, Roberts G. The use of adrenaline autoinjectors by children and teenagers. Clin Exp Allergy 2012;42:284-92.

2011

Randall, KL, Chan SSY, Ma CS, Fung YM, Mei Y, Yabas M, Tan A, Arkwright PD, Al Suwairi W, Oswaldo S, Oswaldo S, Reyes L, Yamazaki-Nakashimada MA, de la Luz Garcia-Cruz M, Smart JM, Picard C, Okada S, Jouanguy E, Casanova JL, Lambe T, Cornall RJ, Russell S, Oliaro J, Tangye SG, Bertram EM, Goodnow CC. Dock8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med 2011;208:2305-20.